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Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid

The conformation with the lowest binding free energy is chosen as the most reasonable binding mode

This condition differs from tolerance, which is the need for increasing doses of opioids to maintain a defined effect (see Dependence)

It also suppresses NF-kB activation and modulates macrophage polarization toward an M2 anti-inflammatory phenotype

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Other common side effects include: red patches, flaky skin, acne purging and dry eyes